loop of Henle as a result of increased urine volume caused by osmotic diuresis. Consequently, the overall reabsorption of water in the collecting ducts is also disrupted, leading to a further increase in urine volume and dilution of urine.
In normal conditions, the loop of Henle plays a critical role in concentrating urine by creating a hyperosmotic medullary environment that allows for significant reabsorption of water in the collecting ducts.